+44 (0)114 215 9667 mellanbycentre@sheffield.ac.uk

Grants 2012 – Present

Government (UK, Europe) and Research Councils

EPSRC
Title: Novel Assessment of the Osteoarthritic Hip Subchondral Bone: a Combined Experimental and Computational Investigation
Holder: Enrico Dall’Ara (PI)
Dates: September 2017 to August 2018
Amount: £102,000

BBSRC
Title: Targeting mechanisms of ageing to maintain musculoskeletal health
Holders: Enrico Dall’Ara, Bellantuono (PI)
Dates:  October 2017 to Sep2019
Amount: £261,000

NIHR 
Title: Establishing clinical phenotype and diagnostic criteria in adult-onset hypophosphatasia
Holders: Richard Eastell (PI), Jennie Walsh
Dates: April 2015 to March 2017
Amount: £200,000

MRC/NIHR EME Award 
Title: Randomised controlled trial of selenium in older women with osteopenia
Holders: Richard Eastell, Jennie Walsh (PI), Cindy Cooper
Dates: April 2016 to May 2018
Amount: £461,057

Health Quality Improvement Partnership                                         
Title: NJR Data Access Portal Development
Grant Holder: Kadirkamanathan, Wilkinson, Hills, Northgate Information Solutions
Awarded 2015            
£140,980

NHS Y&H Innovations Health & Wealth
Title: Bone vibration as a novel screening tool for long bone fractures in children
Grant holder: Dr Amaka Offiah
Awarded Jan 2014
£13,950

NIHR Research Capacity Fund
Title: ABACUS: Assessing Bone health in Children’s bones Using existing and novel imaging techniqueS
Grant holder: Dr Amaka Offiah
Awarded October 2014
£10,326

National Institute for Health Research
Title: ‘Replacing conventional spine radiographs with dual energy x-ray absorptiometry in children with suspected reduction in bone density’
Grant holder: Dr Amaka Offiah
Awarded 20.07.12
£180,990

National Institute for Health Research
Title: ‘Investigation into the relationship between serum oestradiol and other hormones and the risk of osteporotic vertabral fractures using novel imaging technology and measurement of biochemical markers’
Grant holder: Professor Richard Eastell
Awarded 13.0712
£235,060

National Joint Registry
HQIP – Health Quality Improvement Partnership
Title: ‘National Joint Register DNA BioBank’
Grant holder: Professor Mark Wilkinson

European Commission
‘DOHealth’
Grant holder: Professor Eugene McCloskey
Awarded 29 June 2012
£31,031

Department of Health (Policy Research Programme)
Title: The effect of body weight on vitamin D metabolism
Grant holder: Professor Richard Eastell
Awarded June 2012
£625,000

National Institute for Health Research
Title: ‘Effect of metal ions after hip resurfacing on bone health’
Grant holder: Dr Alison Gartland & Professor Mark Wilkinson
Awarded 25.05.2012
£71,187

National Institute for Health Research
Title: ‘Quantification of vertebral structure and strength by image and finite elements analyses of QCT and DXA scans’
Grant holder: Dr Lang Yang
Awarded 25.05.12
£71,187

National Institute for Health Research
Title: Investigation into the relationship between serum oestradiol and other hormones and the risk of osteoporotic vertebral fractures using novel imaging technology and measurement of biochemical markers (Fellowship for Dr Miguel Debono)
Grant holders: Dr Miguel Debono and Professor Richard Eastell                                        
Awarded 01.04.12 – 28.02.14
£235,060

AstraZeneca UK Ltd
Title: ‘SHINE study’
Grant holder: Professor Richard Eastell
Awarded 09.12.11
£23,500

Department of Health
NIHR Senior Investigator Award
Grant holder: Professor Richard Eastell
Awarded 01.04.09 – 31.03.14
£75,000
New Award 01.04.14 – 31.03.17
£45,000

Canadian Institutes of Health Research
Title: Nitrates and bone turnover (NABT): trial to select the best nitrate preparation. 
Grant holders: S Jamal, S Cummings, R Eastell and L Langsetmo
Awarded 01.04.12 – 01.04.14
$263,914 CAD

Charity

Arthritis Research UK
Title: Development and Evaluation of a Functional Prototype for the Automated Identification of Osteoporotic Vertebral Fractures: VERDICT
Holders: Professor Alenjandro Frangi, Dr Jose M Pozo Soler, Dr Margaret Paggiosi, Professor Richard Eastell, Dr Nicola Peel, Dr Richard Jacques
This is a collaborative, translational research project between the following:
Centre for Computational Imaging & Simulation Technologies in Biomedicine (CISTIB)
The Mellanby Centre for Bone Research, Department of Oncology and Metabolism, Faculty of Medicine, University of Sheffield
The Metabolic Bone Centre, Musculoskeletal Directorate, Sheffield Teaching Hospitals NHS Foundation Trust
The Medical Statistics Group, School of Health and Related Research (ScHARR), University of Sheffield
Dates: 01.04.17 to 31.03.19
£98,735.09

Weston Park Hospital Cancer Charity Louise Victoria Craddock Memorial Fund
Title: Establishing new, state-of-the-art research DXA imaging equipment in Sheffield to improve cancer patient care, clinical outcome and quality of life
Holders: Dr Margaret Paggiosi, Professor Richard Eastell, Professor Janet Brown
Dates: 01.11.16 to 30.04.17
£116,441.60

Wellcome Trust
Title: Development of selective Adrenomedullin-2 receptor antagonists for treatment of pancreatic cancer
Holders: Tim Skerry (PI), Gareth Richards
Dates: To continue from current grant from August 2017, end dates currently being negotiated
£2 million

Weston Park Cancer Charity                                                            
Title: Validating the roles of IL-1B and IL-1RA as novel predictors of breast cancer bone metastisis
Grant Holder: Ottewell, Holen, Wilkinson
Awarded 2015            
£98,663

Arthritis Research UK                                                
Development of a Personalized Health Forecasting Tool for Patients Undergoing Hip or Knee Replacement
Grant Holder: Wilkinson, McCloskey, Kadirkamanathan, Blom
Awarded 2015
£244,694

Sheffield Hospitals Charity                                                                 
OsteoPro: A Software System for Assessing Osteoporosis Progression using a Sheffield-born Innovation based on High-Spatial- Resolution Bone Densitometry with DXA Region-Free Analysis
Grant Holder: Prof Mark Wilkinson
Awarded 2015            
£15,715

Orthopaedic Research UK                                         
Title: Biological effects of tribocorrosion products on the bone micro-environment and prosthesis osseo-integration
Grant Holder: Wilkinson, Gartland, Shah
Awarded 2015            
£93,245

Arthritis Research UK/MRC                                                   
Title: CIMA PhD studentship
Grant Holder: Prof Mark Wilkinson
Awarded 2014            
£94,000

The Cavendish Hip Foundation                                              
Title: Cavendish Hip Foundation BMedSci Studentships
Grant Holder: Prof Mark Wilkinson
Awarded 2014            
£30,000

ARUK
Title: Optimisation of a novel magnetic resonance imaging-based scoring system for assessing disease activity in children with juvenile dermatomyositis
Grant holder: Dr Amaka Offiah
Awarded 01.11.13
£51,773

ARUK/MRC Centre of Excellence in Musculoskeletal Ageing Research
Centre for Integrated Research into Musculoskeletal Ageing (CIMA)  (Collaboration Agreement
Uni Liverpool, Uni Newcastle Upon Tyne, Uni Sheffield)
Grant holders: Professor Eugene McCloskey and Professor Richard Eastell,              
(others from Sheffield include: A G Wilson, I Bellantuono)
Awarded: 01.06.12 – 31.05.17
£574,726

National Osteoporosis Society
Title: Clinical evaluation of a free vitamin D assay
Grant Holders: Eastell R, Walsh JS, Naylor KE, Evans L, Keevil B, Wilkinson JM
Awarded 2015-2017
£60,000

Weston Park Hospital Cancer Charity
Title: The effects of prostate cancer and its treatment on bone health
Grant Holders: Brown J, Walsh JS, Rosario D, Ferguson C, Eastell R
Awarded 2014-2016
£100,000

Cancer Research UK
Title: Testosterone replacement in young male cancer survivors
Grant Holders: Ross RJ, Walsh JS, Greenfield DG, Coleman RE, Huddart R, Brown J, Thorpe H, Pavitt S
Awarded 2010-2015
£500,000

Weston Park Hospital Cancer Charity
Title: Testosterone replacement in young male cancer survivors
Grant Holders: Walsh JS, Ross, RJ, Greenfield DG, Coleman RE, Huddart R, Brown J, Thorpe H, Pavitt S
Awarded 2010-2015
£44,000

The Sheffield Children’s Hospital Charity
Title: Employing HRpQCT towards a better understanding of children’s bone geometry in osteogenesis imperfect
Grant holder: Dr Amaka Offiah
Awarded February 2014
£25,998

MRC Mechanisms of Disease Call in collaboration with the University of Leeds.
Sheffield PI: Professor Richard Eastell, Leeds PI: Professor Paul Stewart
01.06.13 – 31.05.15
£390,000

Breast Cancer Campaign
Title: ‘The role of LOX in cancer metastasis to bone’
Grant holder: Dr Alison Gartland
Awarded 06.07 12
£192,378

Foundation for the Study of Infant Deaths
Title: ‘CONI programme 2012/12’
Grant holder: Professor Nick Bishop
Awarded 25.05.12
£83,800

LLR Project Grant 12042
Title: ‘Combination treatment for the eradication of multiple myeloma based on engineered human proteins with no toxicity to normal cells’
Grant holders: Dr Srdjan Vitovski, Dr Andrew Chantry & Professor Jon Sayers
Awarded 17 July 2012
£249,574

The Children’s Hospital Charity
Title: ‘Direct strength testing of bone in infants and children’
Grant holder: Professor Nick Bishop
Awarded 20 January 2012
£44,420

Industry

Alexion Ltd
Title: Phase 1 development of a dynamic Radiological Electronic Atlas of Malformation Syndromes (dREAMS) – essentially a knowledge base and ontology for diagnosing skeletal dysplasias in collaboration with Certus Tech Ltd
Grant holder: Dr Amaka Offiah
Awarded 01.09.17 – 28.02.19
Award: £87,440

MRC/AZ
Title: Mechanisms of Disease Call in collaboration with the University of Birmingham. This is to use an 11-beta hydroxysteroid dehydrogenase inhibitor for the prevention of osteoporosis.
Grant holder: Professor Richard Eastell
Awarded 01.06.13 – 31.05.15
Total Award £390,000. Sheffield to be awarded up to half this amount.

Immunodiagnostic Systems
Title: ‘Study of bone turnover markers in chronic kidney disease’
Sheffield PI: Professor Richard Eastell
01.04.14 to 31.03.16
£37,500

Immuno Diagnostic Systems
PhD student collaboration 
Grant holder: Professor Richard Eastell
Awarded 01.04.14 – 31.03.17
£26,000

AstraZeneca UK Ltd
Title: Phase 1, open-label, multicentre study to assess the safety, tolerability, pharmacokinetics and preliminary anti-tumour activity of ascending doses of AZD4547 in patients with advanced solid malignancies – extension and budget uplift
Grant holder: Professor Richard Eastell
Awarded 01.01.14 – 30.09.15
£58,752

AstraZeneca UK Ltd
Title: SHINE study – extension and budget uplift
Grant holder: Professor Richard Eastell
Awarded 01.07.13 – 31.12.16
£83,037

AstraZeneca
Title: ‘Extension and budget uplift to 129780’
Grant holder: Professor Richard Eastell
Awarded 20.07.12
£15,000

AstraZeneca UK Ltd: AZD4547 D2610C00010
Title: A phase I/IIa trial of AZD4547 in combination with cisplatin and capecitabine (CS)
Grant holder: Professor Richard Eastell
Awarded 01.04.12 – 31.12.15
£81,576

Amgen Ltd
Title: ‘Bone BRU clinical study – Denosumab THA’
Grant holder: Professor Mark Wilkinson
Awarded 23.03.12
£56,560

Immunodiagnostic Systems (IDS)
Title: ‘Proposal to evaluate bone turnover markers in osteoporosis’
Grant holder: Professor Richard Eastell
Awarded 02.12.11
£60,000

Amgen Ltd (through STH)
Title: An open label, single arm, extension study to evaluate the long term safety and efficacy of denosumab (AMG162) in the treatment of postmenopausal osteoporosis
Grant holder: Professor Richard Eastell & Prof Eugene McCloskey            
Awarded 01.04.06 – 31.03.11 Extended to 31.12.16
Original award £25,875
New award £45,320