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Mellanby Members Database

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European Cancer and Bone Metastasis Laboratory (ECBML)

ECBML, a European associated laboratory on cancer and bone metastasis, has recently been created under the auspices of INSERM (french national institute of health and medical research) and the University of Sheffield, Sheffield, UK. This laboratory is to formalise complementary capabilities between Professor Clézardin’s INSERM laboratory in Lyon and the clinical and laboratory based bone oncology researchers in Sheffield. The Mellanby Bone Centre is the umbrella organisation under which ECBML will conduct this 4-year research and training program.

ECBML‘s research program aims at (i) investigating the roles of axon guidance receptors and of RANK/RANKL in mediating the residence of breast cancer cells in the osteogenic niche and (ii) identifying tumour-derived miRNAs that are predictive of relapse in postmenopausal women with early, hormone-responsive breast cancer.This research program is likely to extend in the near future to other key aspects of musculoskeletal diseases that are currently investigated in Lyon and Sheffield. An additional objective for ECBML is to promote exchanges of students and young researchers between the groups and capitalize on the expertise of each side, including access to techniques, facilities and equipments. Overall, this program will reinforce the international visibility of both groups and provide a springboard for European and international funding programs which can be used to develop larger-scale collaborative projects.

ShARM (Shared Ageing Research Models)

ShARM (Shared Ageing Research Models), aims to accelerate research into ageing by enabling the sharing of tissue and information from aged mice and encouraging collaboration in the aged research community. ShARM is a not for profit organisation, funded by the Wellcome Trust and open to all scientific investigators in the UK and overseas. It provides rapid and cost effective access to tissues from aged murine models by means of a biorepository stocked with over 17,000 flash frozen and formalin fixed tissues. ShARM also maintains a database of live ageing colonies which allows for the collection of bespoke samples not already stored in the biorepository. These activities ensure maximum research capacity is attained for all existing aged mouse models, thereby reducing waste and upholding the principles of refining, reducing and replacing the use of animals in research. ShARM promotes the networking of researchers and dissemination of knowledge on ageing research and aged animal welfare through its online collaborative environment; MICEspace. ShARM has supplied approximately 200 tissues to investigators who have used tissues in publications such as in Aging Cell* and to generate preliminary data for grant applications.

Semi-automated Hip Morphology Software Programme (SHIPS)

Hip-joint shape is an important factor that affects an individual’s risk of developing osteoarthritis (OA). SHIPS is a Matlab-based Semi-automated HIP Software program that measures 10 morphologic characteristics of the hip that are risk factors for OA using a plain digitised antero-posterior pelvic radiographs.

The SHIPS software is now available to download:

Download SHIPS.m [.zip]

Download Instructions on SHIPS usage [.docx]

skelet.AL (former Bone Analysis Laboratory)

Part of the Mellanby Centre for Bone Research, skelet.AL (formerly the Bone Analysis Lab) has a diversified expertise in imaging, histology, and bone biology. More>

Biochemistry Laboratory

The biochemistry laboratory is responsible for the measurement of biochemical markers of bone turnover. More>

Bone Imaging Suite (in the Clinical Research Facility)

The Suite has a team of dedicated scan technicians who have undergone formal training and accreditation from the National Osteoporosis Society. They perform a wide range of bone densitometry techniques using specialized equipment for the evaluation of bone density and the structural (including geometric and micro-architectural) properties of bone. More>