Professor Graham Russell, PhD, DM, FRCP, FRCPath. FMedSci, FRS.
Professor of Musculoskeletal Pharmacology, and Botnar Research Centre, University of Oxford; Mellanby Centre for Bone Research, University of Sheffield
Understanding the causes of bone and joint diseases and the pharmacology of drugs to improve their treatment
Tel: +44 (0) 7768 502842
Graham’s research interests include bone cell biology, cytokines, pathogenic mechanisms in bone and joint diseases such as arthritis, myeloma, bone metastases, and osteoporosis, and the evaluation of new therapeutic agents and their modes of action.
Throughout he has played a central role in studying the biological effects of bisphosphonates, and in their clinical development and evaluation for the treatment of skeletal diseases. During the 1990s, Michael Rogers and others within his group in Sheffield elucidated the molecular mechanisms of action of the bisphosphonates, and showed that nitrogen-containing bisphosphonates act as inhibitors of mevalonate metabolism resulting in inhibition of protein prenylation. His current research focuses on understanding their structure activity relationships, the design of novel compounds, and the detailed mechanisms of their actions on the skeleton and other systems.