+44 (0)114 215 9667 mellanbycentre@sheffield.ac.uk

Grants 2015 – Present

Government (UK, Europe) and Research Councils

 

National Institute of Health (US)
Title: Predicting Fast Bone Mineral Density Decline and Fracture Across the Menopause Transition, 
Grant holder: Professor Richard Eastell
Co-applicant: Dr Albert Shieh (UCLA)
Date: 6.5.2020-30.4.2025
$327,420 (Sheffield contribution)

NIHR (RfPB)
Title: Developing normative values for vertebral morphology in children: A feasibility study 
Grant holder: Dr Amaka Offiah
Co-applicants: Nicola Crabtree N (Birmingham) and Jonathan Taylor (Sheffield Teaching Hospitals).
Date: 1 April 2020-30 Sept 2021
£57,054

EU Horizon 2020
Title: Innovative Training Network: Diabetes and Bone
Grant Holder: Professor Richard Eastell
Date: 2 Jan 2020
£256,000

NIHR Rare Disease Translational Research Collaboration
Title: Establishing clinical phenotype and diagnostic crieria in adult-onset hypophosphatasia
Grant Holder: Eastell, R
Date: 2019
£54,292

Charlie Veale Research Award   
Title: High bone mass Osteogenesis Imperfecta Study. Dec 2017
Grant Holder: Balasubramanian M (PI)
Date: 2017-2018
£14,995

Brittle Bone Society Research Grants 
Title: Assessing the Balance of Cost and Determining the Experiences of Families in Paediatric Osteogenesis Imperfecta Healthcare (ABCD Study)
Grant Holder: Balasubramanian M
£9,958 
Date: 2017-2018

National Centre for replacement, refinement and reduction of animal use in research
Title: In silico approaches for preclinical assessment of bone changes in osteoporosis and osteoarthritis studies
Grant Holders: Dall’Ara E (PI), Bellantuono I, Viceconti M
Dates: 2017-2020
£353,000

Arthritis UK, Medical Technologies Proof of Concept Award
Title: Development and Evaluation of a Functional Prototype for the Automated Identification of Osteoporotic Vertibral Fractures: VERDICT
Grant Holder: Professor Alejandro Frangi (PI)
Dates: 2017-2019
£100,000

NIHR Research Capacity Funding Award 2014-15
Grant Holders: Balasubramanian M (PI), Bexon J, Bowen J
Dates: Aug 2014-April 2015
£9,974.00

EPSRC

Title: Novel Assessment of the Osteoarthritic Hip Subchondral Bone: a Combined Experimental and Computational Investigation
Grant Holder: Enrico Dall’Ara (PI)
Dates: Sept 2017 to Aug 2018
£102,000

BBSRC
Title: Targeting mechanisms of ageing to maintain musculoskeletal health
Grant Holders: Enrico Dall’Ara, Bellantuono (PI)
Dates:  Oct 2017 to Sept 2019
£261,000

NIHR 
Title: Establishing clinical phenotype and diagnostic criteria in adult-onset hypophosphatasia
Grant Holders: Richard Eastell (PI), Jennie Walsh
Dates: April 2015 to March 2017
£200,000

MRC/NIHR EME Award 
Title: Randomised controlled trial of selenium in older women with osteopenia
Grant Holders: Richard Eastell, Jennie Walsh (PI), Cindy Cooper
Dates: April 2016 to May 2018
£461,057

Health Quality Improvement Partnership                                         
Title: NJR Data Access Portal Development
Grant Holder: Kadirkamanathan, Wilkinson (PI), Hills, Northgate Information Solutions
Awarded 2015            
£140,980

 

Charity

CIMA
Title: microRNA and fracture in the OPUS Study
Grant Holder: Eastell, R
Date: 7 June 2019
£58,102

Newlife Foundation for Disabled Children
Title: Identification of novel phenotypes in a cohort of children with bone fragility and autism
Dates: June 2015-June 2016
£15,000

The Children’s Charity, Sheffield
Title: Exome sequencing in Osteogenesis Imperfecta
Grant Holders: Balasubramanian M, Dalton A, Bishop NJ
Dates: March 2015-April 2017
£31,669.90

The Children’s Hospital Charity, Sheffield
Title: Exploring the functionality of a new gene in bone fragility and its role in autism
Grant Holders:  Balasubramanian M, Brown S, Roehl HE and Skerry, T
Dates: Aug 2015-Oct 2016

Newlife Foundation for Disabled Children
Title: Digital disease phenotypig in inerited bone fragility disorders
Grant Holders: Dr Meena Balasubramanian, Professor Damien Lacroix, Dr Margaret Paggiosi and Professor Nick Bishop
Dates: Sept 2015-Sept 2016

The Children’s Hospital Charity, Sheffield
Title: Phenotype based assays in Osteogenesis Imperfecta
Grant Holders: Dr Meena Balasubramanian, Professor Damien Lacroxi, Dr Margaret Paggiosi and Professor Nick Bishop
Dates: April 2016
£26,954

 

Arthritis Research UK
Title: Development and Evaluation of a Functional Prototype for the Automated Identification of Osteoporotic Vertebral Fractures: VERDICT
Grant Holders: Professor Alenjandro Frangi, Dr Jose M Pozo Soler, Dr Margaret Paggiosi, Professor Richard Eastell, Dr Nicola Peel, Dr Richard Jacques
This is a collaborative, translational research project between the following:
Centre for Computational Imaging & Simulation Technologies in Biomedicine (CISTIB)
The Mellanby Centre for Bone Research, Department of Oncology and Metabolism, Faculty of Medicine, University of Sheffield
The Metabolic Bone Centre, Musculoskeletal Directorate, Sheffield Teaching Hospitals NHS Foundation Trust
The Medical Statistics Group, School of Health and Related Research (ScHARR), University of Sheffield
Dates: 1 April 2017-31 March 2019
£98,735.09

 

Weston Park Hospital Cancer Charity Louise Victoria Craddock Memorial Fund
Title: Establishing new, state-of-the-art research DXA imaging equipment in Sheffield to improve cancer patient care, clinical outcome and quality of life
Grant Holders: Dr Margaret Paggiosi, Professor Richard Eastell, Professor Janet Brown
Dates: 1 Nov 2016-30 April 2017
£116,441.60

 

Wellcome Trust
Title: Development of selective Adrenomedullin-2 receptor antagonists for treatment of pancreatic cancer
Grant Holders: Tim Skerry (PI), Gareth Richards
Dates: To continue from current grant from August 2017, end dates currently being negotiated
£2 million

 

Weston Park Cancer Charity                                                            
Title: Validating the roles of IL-1B and IL-1RA as novel predictors of breast cancer bone metastisis
Grant Holder: Ottewell, Holen, Wilkinson
Awarded 2015            
£98,663

 

Arthritis Research UK                                                
Development of a Personalized Health Forecasting Tool for Patients Undergoing Hip or Knee Replacement
Grant Holder: Wilkinson (PI), McCloskey, Kadirkamanathan, Blom
Awarded 2015
£244,694

 

Sheffield Hospitals Charity                                                                 
OsteoPro: A Software System for Assessing Osteoporosis Progression using a Sheffield-born Innovation based on High-Spatial- Resolution Bone Densitometry with DXA Region-Free Analysis
Grant Holder: Prof Mark Wilkinson
Awarded 2015            
£15,715

 

Orthopaedic Research UK                                         
Title: Biological effects of tribocorrosion products on the bone micro-environment and prosthesis osseo-integration
Grant Holder: Wilkinson (PI), Gartland, Shah
Awarded 2015            
£93,245

 

Industry

 

Alexion Ltd
Title: Clinical consequences of adult-presenting hypophosphatasia with special focus on gait, bone microarchitecture and cognition: the PORTRAIT Study
Grant holder (50%): Professor Richard Eastell
Awarded: 07.01.20
Awarded: £269,000

Roche Diagnostics
Title: Clinical utility of PINP: the POSE Study
Grant holder: Professor Richard Eastell
Awarded: 22 Nov 2019
Award: £99,000

Genzyme
Title: Commitment from Genzyme for high throughput RNA sequencing and TGF-B antibody work-up in cultured fibroblasts from patients with Osteogenesis Impertecta to identify novel pathways for diagnosis and intervention.
Grant holder: M Balasubramanian,Y  Sabbagh
Award: $88,000

Alexion Ltd
Title: Phase 1 development of a dynamic Radiological Electronic Atlas of Malformation Syndromes (dREAMS) – essentially a knowledge base and ontology for diagnosing skeletal dysplasias in collaboration with Certus Tech Ltd
Grant holder: Dr Amaka Offiah
Awarded 1 Sept 2017 – 28 Feb 2019
Award: £87,440