+44 (0)114 215 9667 mellanbycentre@sheffield.ac.uk

Professor Mark Wilkinson MB ChB, PhD, FRCS (Orth)

Professor of Orthopaedics

Understanding the causes of bone diseases associated with prosthetic joints and developing new approaches to their treatment

Email: j.m.wilkinson@sheffield.ac.uk
Tel: +44 (0)114 2714705

    Mark’s principal research interests are in the genetic and metabolic aspects of joint replacement and its associated bone diseases. He has shown that genetic polymorphisms influence osteolysis and risk of heterotopic ossification after hip replacement and published the first study in humans to show that bisphosphonates may suppress bone loss after hip replacement. Other areas of research include the identification of novel biomarkers and imaging techniques for detecting osteolysis, exploration of the molecular mechanisms that underpin its development and novel pharmacological strategies for its treatment. Work on the genetics of osteoarthritis has uncovered novel gene associations with severity and pattern of hip and knee OA, bone remodelling responses to disease, and hip shape. Work on the systemic health effects of metal ion exposure after hip resurfacing has demonstrated effects on bone cells, cardiovascular, and other systems.

    Mark’s principal funding sources are HEFCE, Arthritis Research UK, JointAction, Royal College of Surgeons of England, Cavendish Foundation, John Charnley Trust and industry.

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