A pioneering study, led by Professor Mark Wilkinson from the University of Sheffield’s Department of Oncology and Metabolism in partnership with Sheffield Teaching Hospitals NHS Foundation Trust, found a drug already used to treat osteoporosis, called denosumab, could help to protect the bone from being attacked and prevent the need for some repeat hip replacement operations.
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Dr Syazrah Salam, an Honorary Clinical Fellow in the Department of Oncology and Metabolism, has been invited to give the 2020 Yorkshire Turner Warwick Lecture. The Turner Warwick Lecture is awarded by the Royal College of Physicians to clinical trainees to showcase their research or quality improvement projects. Her lecture will focus on the diagnostic accuracy of non-invasive tests, such as biomarkers and high resolution bone imaging, as replacement for bone biopsy to diagnose renal osteodystrophy. The lecture will be delivered online via the RCP Player on Friday 6 November.
“The Genetic Epidemiology of Joint Shape and the Development of Osteoarthritis” by Mark Wilkinson and Eleftheria Zeggini
In this review from the University of Sheffield and the Helmholtz Institute in Munich, we review the genetics that underpin how joint shape develops. We also explore how this can influence an individual’s risk of developing osteoarthritis, one of the world’s most common, chronic conditions.
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Arthritis drugs could be repurposed to help prevent breasts cancer spreading to the bone according to new study
- New research from the University of Sheffield uncovers role of protein released by bone marrow in spread of breast cancer to the bone
- Drugs that can block the action of the protein are already in use by the NHS to treat arthritis
- Breast cancer is the UK’s most common cancer and around 11,500 women still lose their lives each year in the UK
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Gwendolyn Bridges (1925-2016), a well-loved local Sheffield resident, has left a very generous legacy gift to support the Mellanby Centre for Bone Research. Please click here for further details.
Dr Meena Balasubramanian was a member of the Faculty at the 4th International Diabetes and International Conference – DECON 2018, on 14th and 15th April, Coimbatore, India
Dr Meena Balasubramanian co-presented the BOND ERN White Paper in the European Parliament, Brussels, on 28 February 2018 .
Sarcoma Research Unit, a new European Research Laboratory in the Mellanby Centre
The “Sarcoma Research Unit”, a European associated Laboratory on the pathogenesis of sarcomas has been created for 4 years (2016-2020) at the interface between the University of Sheffield, INSERM (French national research institute of health and medical research) and the University of Nantes (Professor F. Gouin, France). This research laboratory headed by Professor Dominique Heymann aims to characterize the tumour microenvironment, its role in the control of cancer cell dormancy/proliferation and metastatic process for the identification of new therapeutic targets and development of new therapies. The project is more specifically focused on the analysis of tumour heterogeneity at the single cell level. This new European Associated Laboratory will contribute to the international visibility of the Mellanby Centre and will strengthen the international recognition of both groups in the field of bone sarcoma.
13 August 2016
Predicting human movements
Smart multiscale models of human joints and muscles are being developed by bioengineers in the Insigneo Institute for in silico Medicine, which will give clinicians the power to assess the risk of bone fractures in patients with osteoporosis and help predict the onset and development of Parkinson’s disease.
2 August 2016
Statement from the IOF based on a paper published by Professor Richard Eastell et al. on bone turnover markers.
29 November 2015
Sedentary Lifestyle Making Bones Brittle
27 May 2015
Scientists identify key to preventing secondary cancers
- 12,000 people die in the UK every year from breast cancer
- The most common site for the disease to spread is the bone
- Existing class of drugs for osteoporosis could stop the spread of the disease
Leading scientists from the University of Sheffield and University of Copenhagen have identified a possible key to preventing secondary cancers in breast cancer patients, after discovering an enzyme which enhances the spread of the disease.
Can Bone Biopsy become a thing of the past for CKD patients?
News article in Kidney Life (page 10).
July 2014 The American Society for Bone and Mineral Research gives awards to eight leading scientists in the field of bone and mineral each year. This year, two of the awards have gone to members of the Mellanby Centre:
· Professor Richard Eastell received the Frederic C Bartter Award for outstanding clinical investigation in disorders of bone and mineral metabolism
· Graham Russell received the Gideon A. Rodan Excellence in Mentorship Award in recognition of outstanding support provided by a senior scientist who has helped promote the independent careers of young investigators in bone and mineral metabolism –
26 February 2014 The National Joint Registry is delighted to welcome Professor Mark Wilkinson to the NJR Steering Committee as the Epidemiologist and Public Health member this month.
13 January 2014 – Professor Nick Bishop, Professor of Paediatric Bone Disease at the University of Sheffield, appeared on the BBC Panorama programme ‘I want my baby back’ and says: “From my perspective the programme was flawed by its lack of balance overall; it must have left the public wondering whether or not vitamin D is really important for infant skeletal health and it’s a shame that the message that vitamin D is vital, and that breast fed babies need supplements from early on in order to prevent rickets wasn’t more strongly promulgated.”
October 10, 2013 – Professor Richard Eastell, Director of the Mellanby Centre for Bone Research at the University of Sheffield was the clinical co-chair of the American Society for Bone and Mineral Research held in Baltimore from 5-8 October 2013. This is the largest bone meeting world-wide and was attended by over 5,000 delegates who heard about the latest advances in bone research.
2011/12 – The investigators in the Mellanby Centre have received over £2 million in new grant funding during 2011/2012. This includes being awarded national centre status as Medical Research Council/Arthritis Research UK Centre for Musculoskeletal Ageing with the Universities of Liverpool and Newcastle