Clinical research interests span skeletal diseases of childhood through to the elderly person – from childhood bone diseases (including osteogenesis imperfecta and osteopetrosis) to metabolic bone diseases such as osteoporosis, tumour-induced bone diseases such as multiple myeloma and metastatic bone disease (breast and prostate bone metastases) and osteoarthritis and rheumatoid arthritis. The Centre for the Integration of Research into Musculoskeletal Ageing is an Arthritis Research/Medical Research Council Centre of Excellence based at the Universities of Sheffield, Liverpool and Newcastle (CIMA).
Our clinical research is underpinned by a world-class programme of basic biomedical research, strengthened by continued investment and the relocation of all laboratory activities to one floor of the newly refurbished Henry Wellcome Laboratories in the Medical School. We have also created two ‘core’ laboratories one for ‘bone biochemistry’ and the other for ‘bone analysis’ each of which are supported by HEFCE-funded and grant-funded technicians. These laboratories contain the latest automated immunoassay analysers and ‘state of the art’ high resolution microCT imaging equipment and the equipment and expertise for undertaking quantitative dynamic bone histomorphometry.